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Purpose: Blepharoplasty is a common surgical technique, performed mainly for aesthetic purposes and for functional disorders of the periorbital, which corrects excess skin of the upper eyelids or excess fat in the lower bags. As a side effect, periorbital hematomas usually occur, which can be annoying for patients. Ice water compresses and head elevation are used, without scientific evidence, for recovery, but specific creams, such as those with lactoferrin, can accelerate tissue repair processes. The study aimed to assess the efficacy of a cream containing lactoferrin encapsulated in liposomes, Kelador®, to reduce post-blepharoplasty bruises. Methods: This controlled, prospective, randomized, single-centre pilot clinical study was conducted at the Barraquer Clinic in Barcelona, Spain. All patients underwent a blepharoplasty, and periorbital hematomas were treated with a Chelating Cream (Kelador®). Patients were followed up two and nine days after surgery, where clinical data and photographs were taken. Images were assessed through an objective analysis method developed with the ImageJ® software. Results: Nineteen patients were enrolled, 16 women and three men. The median age was 60.37 years (SD 14.22), and the median of treatment days was 8.2 (SD 1.6). The mean Reduction % in the treated eyes was 33.3 (SD 31,0), and in untreated eyes, 17.7 (SD38,1). Differences were statistically significant (p = 0.00667). Conclusions: Using a Chelating Cream containing lactoferrin encapsulated in liposomes, such as Kelador®, accelerates the reduction of bruise colour after a periocular intervention such as blepharoplasty.
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